June 11, 2025
By Michael Tiffany and Amna Rana

Are You Optimizing or Over-Optimizing? Longevity Lessons with Nathalie Niddam

Is your health routine actually making you healthier, or just making you more anxious?

In this episode of The Augmented Life, Michael J.J. Tiffany sits down with biohacker and longevity expert Nathalie Niddam to unpack the line between meaningful health optimization and counterproductive obsession.

They dive deep into practical longevity, the role of hormones, light, genetics, wearables, and even peptides, starting with what really matters: How you feel, how you live, and whether you’ve nailed the basics.

Nathalie offers a grounded, systems-thinking approach to health: Test intelligently, live in sync with light and circadian rhythms, move naturally, and don’t skip the fundamentals in your rush to "biohack" your way to 100.

This conversation is for anyone who’s trying to balance data with intuition, modern tech with ancestral wisdom, and optimization with actually enjoying life.

⏱️ Timestamps

00:00 – Intro: Optimization vs over-optimization

01:00 – Why chasing data can backfire on your wellness

04:00 – Foundational health vs fancy interventions

06:30 – How to know if you're actually thriving

09:00 – Light as a missing piece of the wellness puzzle

12:00 – Circadian biology, vitamin D, and UVB tech

15:00 – Behavioral change vs jumping to TRT

18:00 – The role of strength training in longevity

21:00 – Labs that actually matter (and what they tell you)

23:00 – Why most people are taking the wrong supplements

24:30 – Biological age tests and what to do with the data

28:00 – HRV: Overrated, misunderstood, or useful?

32:00 – The value of tuning in before you tune your metrics

35:00 – Genetics as lifestyle feedback, not destiny

39:00 – Living well with APOE4 and other gene variants

42:00 – Why the foundations still matter more than any one hack

44:00 – Peptides, testing, and when to actually start

46:00 – Final advice: Direction > perfection

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